01 // the challenge

The evidence base is too large to read. Too important to skip.

Evidence explosion

8,000+ immunotherapy papers, doubling every 18 months. No human can read fast enough to stay current.

Biomarker proliferation

PD-L1, TMB, MSI-H, dMMR โ€” which claims survive cross-reference? Which are overfitted to small cohorts?

Trial design pressure

Phase 3 trials cost $50M+. You need evidence synthesis before commitment, not after enrollment.

02 // the axion approach

Evidence synthesis that survives adversarial review.

8,269 papers indexed

8,269-paper immunotherapy corpus

Checkpoint inhibitors, CAR-T, combination therapies. PubMed-sourced and indexed by mechanism.

57% rejection rate

Adversarial claim testing

Multi-model pipeline attacks your synthesis. 57% of initial hypotheses fail this gauntlet.

53% fabrications caught

Citation verification

Every DOI checked against live databases. 53% of AI-generated citations contain errors.

03 // results

What the pipeline produces.

8,269 papers analyzed
57% hypothesis rejection
24-48h synthesis turnaround
53% citation errors caught
use case

Combination therapy evidence review: Research team needed to synthesize PD-1/CTLA-4 combination evidence across 3,000+ papers before Phase 2 design. Manual review: 6 weeks. Axion synthesis: 48 hours. Output included 12 contradictions in published response rates and 3 unreported safety signals from post-hoc analyses.

04 // start

Research audit for immunotherapy work.

Send one hypothesis, evidence question, or draft section. We run it through the adversarial pipeline and show you what survives.

One hypothesis or evidence question. We confirm review scope before work starts.

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